events and conference contributions

eBRAIN-Health and TEF-Health summit Berlin - Transforming Healthcare with Trusted AI, Robotics and Data

Alzheimer Europe Magazine - issue 50

scientific publications

Carpi, M., Afragola, A.P., De Bartolo, M. et al.
Abnormal periodic and aperiodic resting-state electroencephalographic markers in Lewy body and Alzheimer’s diseases with cognitive decline.
GeroScience (2026). https://doi.org/10.1007/s11357-026-02325-5

Carpi, M., De Bartolo, M., Henao Isaza, V. et al.
Associations of daily step counts with cognitive, clinical, and resting-state electroencephalographic measures in patients with cognitive decline due to Alzheimer’s disease.
GeroScience (2026). https://doi.org/10.1007/s11357-026-02367-9

Ana Damjanovic, Vincenzo Carnevale, Thorsten Hater, Nauman Sultan, Giulia Rossetti, Sandra Diaz-Pier, Paolo Carloni
From Atoms to Neuronal Spikes: A Multiscale Simulation Framework.
J. Chem. Theory Comput. 27 January 2026; 22 (2): 783–793. https://doi.org/10.1021/acs.jctc.5c01793

Komeyer V, Nieto N, Eickhoff S
Overview of Challenges in Brain-Based Predictive Modeling: Toward Meaningful Predictive Insights
Biological Psychiatry, 2025; 99, 840-850, https://doi.org/10.1016/j.biopsych.2025.09.003

Del Percio, C., Lizio, R., De Bartolo, M. et al.
Performance of the SmartMe&You serious video games for home telemonitoring is related to cognitive status and resting-state electroencephalographic markers in healthy and Parkinson’s disease participants.
GeroScience (2026). https://doi.org/10.1007/s11357-026-02417-2

M. Carpi, V. Henao Isaza, G. Noce, et al.
Periodic and Aperiodic Electroencephalographic Rhythms During Vigilance Transitions in Alzheimer's Disease Mild Cognitive Impairment.
Annals of the New York Academy of Sciences 1555, no. 1 (2026): e70194. https://doi.org/10.1111/nyas.70194

Dickscheid, T., Gui, X., Simsek, A.N. et al.
Siibra: a software tool suite for realizing a Multilevel Human Brain Atlas from complex data resources.
Nat Methods 23, 1647–1658 (2026). https://doi.org/10.1038/s41592-026-03159-x

Ignacio Martín, Gorka Zamora‐López, Jan Fousek, Michael Schirner, Petra Ritter, Viktor Jirsa, Gustavo Deco, Gustavo Patow
TVB C++: A Fast and Flexible Back‐End for The Virtual Brain
Adv. Sci. 13, no. 2 (2026): e06440. https://doi.org/10.1002/advs.202406440

Susanna Lopez, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Dharmendra Jakhar, Andrea Soricelli, Marco Salvatore, Bahar Güntekin, Görsev Yener, Federico Massa, Dario Arnaldi, Francesco Famà, Matteo Pardini, Raffaele Ferri, Filippo Carducci, Bartolo Lanuzza, Fabrizio Stocchi, Laura Vacca, Chiara Coletti, Moira Marizzoni, John-Paul Taylor, Lutfu Hanoğlu, Nesrin Helvacı Yılmaz, İlayda Kıyı, Yağmur Özbek-İşbitiren, Anita D’Anselmo, Laura Bonanni, Roberta Biundo, Fabrizia D’Antonio, Giuseppe Bruno, Angelo Antonini, Franco Giubilei, Sofia Cuoco, Paolo Barone, Giovanni B. Frisoni, Rossella Rotondo, Francesca De Pandis, Claudio Babiloni
The compensatory effect of education as revealed by resting-state electroencephalographic alpha rhythms in patients with dementia due to Parkinson’s disease: findings from an exploratory study
GeroScience 48, 1189–1218 (2026). https://doi.org/10.1007/s11357-025-01703-9

Babiloni C, Lopez S, Noce G, Del Percio C, Lizio R, Jakhar D, De Bartolo M, Ferri R, Carducci F, Catania V, Soricelli A, Salvatore M, Arnaldi D, Famà F, Brugnolo A, Pardini M, Giubilei F, Stocchi F, Vacca L, Coletti C, D'Antonio F, Bruno G, Güntekin B, Hanoğlu L, Yırıkoğulları H, Yener G, Russo G, Marizzoni M, Frisoni GB, Rotondo R, D'Alessandro T, Cilia ND, De Pandis MF, Santoro A, Marziali S, De Stefano C, Fontanella F.
Enriched resting-state EEG prediction of cognitive decline in prodromal Alzheimer's disease: a machine-learning approach.
IClin Neurophysiol. 2026 Mar 25;186:2111860, https://doi.org/10.1016/j.clinph.2026.2111860  

Pumaccola BS, Babiloni C, Fraga FJ.
Deep Learning in Resting-State Electroencephalogram Signals for Classification of Cognitively Healthy Older Adults, Alzheimer’s Disease, and Lewy Body Dementia Patients.
IEEE Access, VOLUME 14, 2026, https://doi.org/10.1109/ACCESS.2026.3675491

Jakhar D, Noce G, Del Percio C, Lopez S, Carducci F, Lizio R, De Bartolo M, Henao Isaza V, Macrì A, Soricelli A, Salvatore M, Ciccarelli G, Galluccio S, Di Cecca A, Aiello M, Güntekin B, Yener G, Massa F, Arnaldi D, Famà F, Pardini M, Ferri R, Lanuzza B, Stocchi F, Vacca L, Coletti C, Marizzoni M, Taylor JP, Hanoğlu L, Yırıkoğulları H, Kıyı Atilla İ, Kula H, Frisoni GB, Cuoco S, Barone P, Bonanni L, D'Anselmo A, Biundo R, Cauzzo S, Fiorenzato E, Antonini A, D'Antonio F, Bruno G, Fabbrini G, Conte A, Leodori G, Giubilei F, Infarinato F, Marziali S, De Pandis MF, Delussi M, Salvatore E, De Tommaso M, Babiloni C.
Abnormal Resting-State EEG delta and alpha rhythms in Huntington's and Alzheimer's Diseases: An exploratory study. Clin Neurophysiol. 2026 Jan 25;184:2111518. doi: 10.1016/j.clinph.2026.2111518. Epub ahead of print. PMID: 41619714.

Carpi M, Henao Isaza V, Noce G, Salamone EM, Del Percio C, Lopez S, Carducci F, Lizio R, De Bartolo M, Jakhar D, Afragola AP, Rossi C, Barjami L, Soricelli A, Salvatore M, Giubilei F, Güntekin B, Yener G, Massa F, Arnaldi D, Famà F, Pardini M, Ferri R, Lanuzza B, Stocchi F, Vacca L, Coletti C, Marizzoni M, Taylor JP,
Hanoğlu L, Yırıkoğulları H, Frisoni GB, Cuoco S, Cappiello A, Barone P, Bonanni L, D'Anselmo A, Biundo R, Cauzzo S, Fiorenzato E, Antonini A, D'Antonio F, Bruno G, Infarinato F, Marziali S, De Pandis MF, Babiloni C. Periodic and Aperiodic Electroencephalographic Rhythms During Vigilance Transitions in Alzheimer's Disease Mild Cognitive Impairment. Ann N Y Acad Sci. 2026 Jan;1555(1):e70194. doi: 10.1111/nyas.70194. PMID: 41589606.

EBRAINS White paper - From Brain Science to Trusted Digital Health Services

scientific reports

Report on Patient Advisory Group activities
Final Legal and Ethical Framework
Legal and ethical helpdesk report
Report on the ethical and social implications of EBRAINS-Health technologies
Knowledge graph adapter for spatial mapping of pathways
Atlas functionality for extraction and organization of spatiotemporal data features
Multi-scale simulation engine accessible via EBRAINS with HPC backend  
ML/DL based Disease stratification models
Inference software suite
Demonstrator intervention
Demonstrator in silico brain stimulation optimization
Public outreach materials   

events and conference contributions

On 4th December 2025, an online meeting with the external legal and ethics advisors of the eBRAIN-Health project took place. In this context, CHARITE together with University of Vienna (UNIVIE) and Alzheimer Europe (AE) presented their work within the project and obtained feedback and guidance on the next steps within the project from the external experts. The legal and ethical advisors are accomplished figures from the fields of ethics, privacy and data protection law, and ICT technology.

Cyberspace Conference in Brno
Representing the eBRAIN-Health project, Klaudia Kwiatkowska and Alexandra Mǎrginean highlighted the legal status of synthetic data under the legal acts of the European Data Strategy, more specifically the Data Governance Act, Data Act and European Health Data Space. The presentation focused on the opportunities and challenges represented by synthetic data in medical research. In the context of the eBRAIN-Health project, synthetic data will be used to enrich machine learning and deep learning algorithms which will support early diagnosis of neurodegenerative diseases.

scientific publications

Lopez S, Del Percio C, Lizio R, Noce G, Jakhar D, Soricelli A, Salvatore M, Güntekin B, Yener G, Massa F, Arnaldi D, Famà F, Pardini M, Ferri R, Carducci F, Lanuzza B, Stocchi F, Vacca L, Coletti C, Marizzoni M, Taylor JP, Hanoğlu L, Yılmaz NH, Kıyı İ, Özbek-İşbitiren Y, D'Anselmo A, Bonanni L, Biundo R, D'Antonio F, Bruno G, Antonini A, Giubilei F, Cuoco S, Barone P, Frisoni GB, Rotondo R, De Pandis F, Babiloni C.
The compensatory effect of education as revealed by resting-state electroencephalographic alpha rhythms in patients with dementia due to Parkinson's disease: findings from an exploratory study. Geroscience. 2025 Jun 11. doi: 10.1007/s11357-025-01703-9. Epub ahead of print. PMID: 40498398

Lopez S, Hampel H, Percio CD, Noce G, Lizio R, Teipel SJ, Dyrba M, González-Escamilla G, Bakardjian H, Chiesa PA, Cavedo E, Vergallo A, Lemercier P, Spinelli G, Grothe MJ, Potier MC, Stocchi F, Coletti C, Ferri R, Pardini M, Habert MO, Marziali S, Dubois B, Babiloni C; and INSIGHT‐preAD study group.
Educational attainment, electroencephalographic rhythms, cortical structure, and cognitive performance over 2 years in older adults with subjective memory complaints and brain amyloidosis. Alzheimers Dement.
2025 Jul;21(7):e70438. doi: 10.1002/alz.70438. Erratum in: Alzheimers Dement. 2025 Aug;21(8):e70577. doi: 10.1002/alz.70577. PMID: 40660738; PMCID: PMC12260118

Enrico Michele Salamone, Matteo Carpi, Giuseppe Noce, Claudio Del Percio, Susanna Lopez, Roberta Lizio, Dharmendra Jakhar, Ali Eldellaa, Veronica Henao Isaza, Burcu Bölükbaş, Andrea Soricelli, Marco Salvatore, Bahar Güntekin, Görsev Yener, Federico Massa, Dario Arnaldi, Francesco Famà, Matteo Pardini, Raffaele Ferri, Michele Salerni, Bartolo Lanuzza, Fabrizio Stocchi, Laura Vacca, Chiara Coletti, Moira Marizzoni, John Paul Taylor, Lutfu Hanoğlu, Nesrin Helvacı Yılmaz, İlayda Kıyı, Hilal Kula, Giovanni B. Frisoni, Sofia Cuoco, Paolo Barone, Anita D’Anselmo, Laura Bonanni, Roberta Biundo, Fabrizia D’Antonio, Giuseppe Bruno, Franco Giubilei, Angelo Antonini, Claudio Babiloni
Abnormal electroencephalographic rhythms from quiet wakefulness to light sleep in Alzheimer’s disease patients with mild cognitive impairment - Clinical Neurophysiology

Del Percio C, Lizio R, Lopez S, Noce G, Carpi M, Jakhar D, Soricelli A, Salvatore M, Yener G, Güntekin B, Massa F, Arnaldi D, Famà F, Pardini M, Ferri R, Carducci F, Lanuzza B, Stocchi F, Vacca L, Coletti C, Marizzoni M, Taylor JP, Hanoğlu L, Yılmaz NH, K
Resting-State EEG Alpha Rhythms Are Related to CSF Tau Biomarkers in Prodromal Alzheimer’s Disease - IJMS

Claudio Del Percio, Roberta Lizio, Susanna Lopez, Giuseppe Noce, Dharmendra Jakhar, Matteo Carpi, Burcu Bölükbaş, Andrea Soricelli, Marco Salvatore, Bahar Güntekin, Görsev Yener, Federico Massa, Dario Arnaldi, Francesco Famà, Matteo Pardini, Raffaele Ferri, Michele Salerni, Bartolo Lanuzza, Fabrizio Stocchi, Laura Vacca, Chiara Coletti, Moira Marizzoni, John Paul Taylor, Lutfu Hanoğlu, Nesrin Helvacı Yılmaz, İlayda Kıyı, Yağmur Özbek-İşbitiren, Giovanni B. Frisoni, Sofia Cuoco, Paolo Barone, Anita D'Anselmo, Laura Bonanni, Roberta Biundo, Fabrizia D'Antonio, Giuseppe Bruno, Franco Giubilei, Francesca De Pandis, Rossella Rotondo, Angelo Antonini, Claudio Babiloni
Resting-state electroencephalographic rhythms depend on sex in patients with dementia due to Parkinson's and Lewy Body diseases: An exploratory study - Neurobiology of Disease

Babiloni C, Arakaki X, Baez S, Barry RJ, Benussi A, Blinowska K, Bonanni L, Borroni B, Bosch JB, Bruno G, Cacciotti A, Carducci F, Carino J, Carpi M, Conte A, Cruzat J, D’Antonio F, Della Penna S, Del Percio C, De Sanctis P, Escudero J, Fabbrini G, Farina
Alpha Rhythm and Alzheimer’s Disease: Has Hans Berger’s Dream Come True? - Clinical Neurophysiology

scientific reports

Open access pathway knowledge graphs
High throughput container workflows
Catalogue of multi-scale principles of brain dynamics in dementia
Patient and clinical user applications
Education app in multiple platforms
Identified biomarkers using explainable AI